A slight reprieve from the onslaught, only 6 articles this month – some of which are really interesting. 1) The Toxicology Investigators Consortium Case Registry-The 2012 Experience. Wiegand T, Wax P, Smith E, Hart K, Brent J. J Med Toxicol. 2013 Nov 1. [Epub ahead of print] Comments: Fascinating TocIC Registry, including cases that wereRead More
PubMed Update September 2013
12 articles this month. 1) Effectiveness of Naltrexone in the Prevention of Delayed Respiratory Arrest in Opioid-Naive Methadone-Intoxicated Patients. Aghabiklooei A, Hassanian-Moghaddam H, Zamani N, Shadnia S, Mashayekhian M, Rahimi M, Nasouhi S, Ghoochani A. Biomed Res Int. 2013;2013:903172. Epub 2013 Sep 9. Comments: Interesting use of the long-acting opioid antagonist naltrexone in this studyRead More
PubMed Update: Another Year in Overdose
Another year in overdose, September 2012-August 2013, generally in reverse chronological order, and following the same loosely-formed categories as last year. Once again, this is opioid focused and misses anything not listed in the PubMed database – which means it misses many interesting papers to which you are warmly welcomed to post links! This yearRead More
PubMed Update August 2013
16 papers today – this is getting to be a big job. Naloxone, fentanyl, methadone, stars, pain, Central Asia, primary care, injection facilities, personal stories … 1) Notes from the field: acetyl fentanyl overdose fatalities – rhode island, march-may 2013. Centers for Disease Control and Prevention (CDC). MMWR Morb Mortal Wkly Rep. 2013 Aug 30;62(34):703-4.Read More
PubMed Update June 2013
13 new papers this month, from drug development to naloxone programming, epidemiology to practice management, toxicology to supply side drug control. 1) Illicit drug overdose – Prevalence and acute management. Li W, Gunja N. Aust Fam Physician. 2013 Jul;42(7):481-5. Comment: Unable to access. Appears to be a general review of managing illicit drug toxicities. 2)Read More
PubMed Update May 2013
Here is the May 2013 roundup with 7 papers and some extra kudos to the authors for important steps forward in data or practice. 1) Ethanol Reversal of Cellular Tolerance to Morphine in Rat Locus Coeruleus Neurons. Llorente J, Withey S, Rivero G, Cunningham M, Cooke A, Saxena K, McPherson J, Oldfield S, Dewey W,Read More
PubMed Update April 2013
10 papers this time. Good stuff. Take-Home Emergency Naloxone to Prevent Heroin Overdose Deaths after Prison Release: Rationale and Practicalities for the N-ALIVE Randomized Trial. Strang J, Bird SM, Parmar MK. J Urban Health. 2013 May 1. [Epub ahead of print] Comment: Really interesting article on the design of the N-ALIVE trial of naloxone provisionRead More
PubMed Update February/March 2013
Another 8 papers on opioid overdose issues. 1) ‘It’s more about the heroin’: injection drug users’ response to an overdose warning campaign in a Canadian setting. Kerr T, Small W, Hyshka E, Maher L, Shannon K. Addiction. 2013 Mar 28. doi: 10.1111/add.12151. [Epub ahead of print] Comment: Interesting qualitative analysis of warnings issued regarding high-potencyRead More
PubMed Update December 2012 – January 2013
This is a really exciting time for research into overdose in general and naloxone in particular. 15 papers this time. Opioid overdose rates and implementation of overdose education and nasalnaloxone distribution in Massachusetts: interrupted time series analysis. Walley AY, Xuan Z, Hackman HH, Quinn E, Doe-Simkins M, Sorensen-Alawad A, Ruiz S, Ozonoff A. BMJ. 2013Read More
PubMed Update October/November 2012
My apologies for tardiness. I’ll try to be on time next month. 13 papers described below. Prevention of fatal opioid overdose. Beletsky L, Rich JD, Walley AY. JAMA. 2012 Nov 14;308(18):1863-4. doi: 10.1001/jama.2012.14205. Comment: An excellent summary of key issues in overdose prevention and increasing naloxone availability for lay overdose reversal. Read it. Management ofRead More