Here is the May 2013 roundup with 7 papers and some extra kudos to the authors for important steps forward in data or practice. 1) Ethanol Reversal of Cellular Tolerance to Morphine in Rat Locus Coeruleus Neurons. Llorente J, Withey S, Rivero G, Cunningham M, Cooke A, Saxena K, McPherson J, Oldfield S, Dewey W,Read More
PubMed Update April 2013
10 papers this time. Good stuff. Take-Home Emergency Naloxone to Prevent Heroin Overdose Deaths after Prison Release: Rationale and Practicalities for the N-ALIVE Randomized Trial. Strang J, Bird SM, Parmar MK. J Urban Health. 2013 May 1. [Epub ahead of print] Comment: Really interesting article on the design of the N-ALIVE trial of naloxone provisionRead More
PubMed Update February/March 2013
Another 8 papers on opioid overdose issues. 1) ‘It’s more about the heroin’: injection drug users’ response to an overdose warning campaign in a Canadian setting. Kerr T, Small W, Hyshka E, Maher L, Shannon K. Addiction. 2013 Mar 28. doi: 10.1111/add.12151. [Epub ahead of print] Comment: Interesting qualitative analysis of warnings issued regarding high-potencyRead More
PubMed Update December 2012 – January 2013
This is a really exciting time for research into overdose in general and naloxone in particular. 15 papers this time. Opioid overdose rates and implementation of overdose education and nasalnaloxone distribution in Massachusetts: interrupted time series analysis. Walley AY, Xuan Z, Hackman HH, Quinn E, Doe-Simkins M, Sorensen-Alawad A, Ruiz S, Ozonoff A. BMJ. 2013Read More
PubMed Update October/November 2012
My apologies for tardiness. I’ll try to be on time next month. 13 papers described below. Prevention of fatal opioid overdose. Beletsky L, Rich JD, Walley AY. JAMA. 2012 Nov 14;308(18):1863-4. doi: 10.1001/jama.2012.14205. Comment: An excellent summary of key issues in overdose prevention and increasing naloxone availability for lay overdose reversal. Read it. Management ofRead More
PubMed Update September 2012
Another busy month in overdose-related research (11 papers), including several toxicology and epidemiology papers, some of which represent novel analytic approaches that serve to advance the field. Oxycodone overdose causes naloxone responsive coma and QT prolongation. Berling I, Whyte IM, Isbister GK. QJM. 2012 Sep 28. [Epub ahead of print] PMID: 23023890 [PubMed – as supplied by publisher] Comment:Read More
PubMed Update: A Year in Overdose
Here is a summary of our first year of PubMed updates. This list is NOT comprehensive and focuses on opioids at the expense of stimulant issues. There are some excellent papers not listed in the PubMed database (e.g. a couple of great papers out of Scotland we’ve discussed here and many conference abstracts). So …Read More
Pubmed Update August 2012
Just one paper to talk about, but I think it warrants discussion. Aversive and reinforcing opioid effects: a pharmacogenomic twin study. Angst MS, Lazzeroni LC, Phillips NG, Drover DR, Tingle M, Ray A, Swan GE, Clark JD. Anesthesiology. 2012 Jul;117(1):22-37. Comment: This is a twin study to look at the genetic contribution to opioid effects.Read More
PubMed July 2012 Update
LOTS of great articles this month (10 total)! Let’s start with an updated chart of the number of scientific opioid overdose articles each year from 1980 through 2011. Injection Drug Users Trained by Overdose Prevention Programs: Responses to Witnessed Overdoses Lankenau SE, Wagner KD, Silva K, Kecojevic A, Iverson E, McNeely M, Kral AH. JRead More
PubMed June 2012 Update
jThis chart was produced in 2007 to demonstrate the increase in overdose literature in the late 1990s and early 2000s – a trend that has continued. Twenty years ago there would have been 1 article for this post every 3-4 months, which may have been okay since you would have received it by actual post.Read More