28 in a month.
Eizadi-Mood N, Yaraghi A, Sharifian Z, Feizi A, Hedaiaty M, Sabzghabaee AM.
Mater Sociomed. 2015 Aug;27(4):276-9. doi: 10.5455/msm.2015.27.276-279.
Comments: Some interesting data on methadone toxicity in Iran. Length of stay was 33 hours (median). 90.3% survived. There were several complications. GCS on admission predicted survival. Useful data for economic modeling …
Zucker H, Annucci AJ, Stancliff S, Catania H.
Harm Reduct J. 2015 Nov 5;12(1):51. doi: 10.1186/s12954-015-0084-8.
PMID: 26541987 Free Article
Comments: Early report describing the establishment of a prison naloxone program in NY. Some of the most important work happening in this area…
Winstanley EL, Clark A, Wilder CM.
J Addict Med. 2015 Dec;9(6):503-4. doi: 10.1097/ADM.0000000000000160. No abstract available.
Comments: Can’t access. Meh.
4) Quality Assessment Errors and Study Misclassification Threaten Systematic Review Validity: Community Opioid Overdose Prevention and Naloxone Distribution Programs Review: Re: Clark AK, Wilder CM, Winstanley EL. A systematic review of community opioid overdose prevention and naloxone distribution programs. J Addict Med 2014 May-June;8(3): 153-163.
Orkin AM, Bingham K, Buick JE, Klaiman M, Leece P, Kouyoumdjian F.
J Addict Med. 2015 Dec;9(6):502-3. doi: 10.1097/ADM.0000000000000161. No abstract available.
Comments: Also can’t access.
Clark A, Winstanley EL, Martsolf DS, Rosen M.
Addict Behav. 2015 Oct 8;53:141-145. doi: 10.1016/j.addbeh.2015.10.006. [Epub ahead of print] No abstract available.
Comments: Authors report on development of an electronic book on overdose prevention for use in addiction treatment settings.
Ashrafioun L, Gamble S, Herrmann M, Baciewicz G.
Subst Abus. 2015 Oct 29:0. [Epub ahead of print]
Comments: Those trained in intranasal naloxone were more confident than those trained in injectable. That is odd, as studies suggest that injectable is easier than intranasal.
Lev R, Petro S, Lee A, Lee O, Lucas J, Castillo EM, Egnatios J, Vilke GM.
Forensic Sci Int. 2015 Oct 22;257:347-352. doi: 10.1016/j.forsciint.2015.09.021. [Epub ahead of print]
Comments: The lack of data from methadone maintenance programs makes it quite challenging to interpret some of the methadone-related mortality data.
McAuley A, Aucott L, Matheson C.
Int J Drug Policy. 2015 Oct 1. pii: S0955-3959(15)00306-0. doi: 10.1016/j.drugpo.2015.09.011. [Epub ahead of print]
Comments: 9% of kits were likely to be used for overdose rescue. That looks like a rather low number, but it’s over a 3-month period. I suspect the annual rate is closer to 20% +/- 5%.
Davis CS, Carr D.
Drug Alcohol Depend. 2015 Oct 22. pii: S0376-8716(15)01695-6. doi: 10.1016/j.drugalcdep.2015.10.013. [Epub ahead of print]
Comments: Great paper, title says it all.
Jolley CJ, Bell J, Rafferty GF, Moxham J, Strang J.
PLoS One. 2015 Oct 23;10(10):e0140995. doi: 10.1371/journal.pone.0140995. eCollection 2015.
Comments: I like this study. The physiology of “overdose” is totally fascinating and nowhere near as simple as it seems.
Baillif-Couniou V, Kintz P, Sastre C, Pok PP, Chèze M, Pépin G, Leonetti G, Pelissier-Alicot AL.
J Forensic Leg Med. 2015 Sep 4;36:172-176. doi: 10.1016/j.jflm.2015.08.014. [Epub ahead of print]
Comments: Morphine overdose in an adolescent in France. It’s news there because they don’t see people dying of prescription opioids like in the U.S.
Wiebelhaus JM, Walentiny DM, Beardsley PM.
J Pharmacol Exp Ther. 2015 Oct 21. pii: jpet.115.228940. [Epub ahead of print]
Comments: Oxycodone works like other opioids.
Tucker D, Hayashi K, Milloy MJ, Nolan S, Dong H, Kerr T, Wood E.
Addict Behav. 2015 Oct 9;52:103-107. doi: 10.1016/j.addbeh.2015.10.002. [Epub ahead of print]
Comments: Benzo use is associated with lots of risk factors for negative health outcomes, including blood-borne virus transmission, among drug users.
Addiction. 2015 Nov;110(11):1775-6. doi: 10.1111/add.13093. No abstract available.
Comments: Nice commentary, pointing out the opportunities for intervention among those who contact the medical system with an overdose.
Br J Clin Pharmacol. 2015 Aug 7. doi: 10.1111/bcp.12731. [Epub ahead of print] Review.
Comments: Fascinating differences between benzo and opioid-induced respiratory depression. Benzos cause apnea usually because the upper airway is blocked or collapses – so respiratory support is the need – and the antidote can lead to seizures. Opioids are different and naloxone much safer.
Cheatle MD, Webster LR.
Pain Med. 2015 Oct;16 Suppl 1:S22-6. doi: 10.1111/pme.12910. Review.
Comments: Opioids might be dangerous with sleep disorders.
Morris MD, Bates A, Andrew E, Hahn J, Page K, Maher L.
Drug Alcohol Depend. 2015 Nov 1;156:275-81. doi: 10.1016/j.drugalcdep.2015.09.025. Epub 2015 Sep 30.
Comments: Injection partnerships can have divergent benefits and risks.
18) A True Antidote.
Tex Med. 2015 Oct 1;111(10):41-7.
Comments: Naloxone in Texas!
Lake S, Hayashi K, Buxton J, Milloy MJ, Dong H, Wood E, Montaner J, Kerr T.
Drug Alcohol Depend. 2015 Nov 1;156:297-303. doi: 10.1016/j.drugalcdep.2015.09.026. Epub 2015 Sep 30.
Comments: Interesting analysis – injecting prescription opioids didn’t by itself increase overdose risk. Injecting of both prescription opioids and heroin did, however. So there is probably some protection offered by the known doses and constituents in prescription opioids.
Martins SS, Sampson L, Cerdá M, Galea S.
Am J Public Health. 2015 Nov;105(11):e29-49. doi: 10.2105/AJPH.2015.302843.
Comments: Nice summary of global data looking at some basic overdose results. Mean/median rate of witnessed overdose in a drug user’s lifetime = 73/70%. Lifetime prevalence of experienced overdose was mean of 45.4% and median of 47%. Population-based overdose mortality rates varied from 0.4-46.6 / 100,000 person years (note, this is population based).
Health Aff (Millwood). 2015 Oct 1;34(10):1624-7. doi: 10.1377/hlthaff.2015.0934.
Comments: Review of naloxone based on summer 2015 FDA meeting.
Vaccine. 2015 Oct 2. pii: S0264-410X(15)01369-9. doi: 10.1016/j.vaccine.2015.09.079. [Epub ahead of print] Review.
Comments: Really interesting idea – use antibodies against drugs, like cocaine, to manage overdose on those drugs. Excellent.
Partownavid P, Sharma S, Li J, Umar S, Rahman S, Eghbali M.
Anesth Analg. 2015 Aug;121(2):340-7. doi: 10.1213/ANE.0000000000000788.
Comments: Opioid receptors are required for rescuing people from the cardiac toxicity of bupivacaine overdose.
Rech MA, Donahey E, Cappiello Dziedzic JM, Oh L, Greenhalgh E.
Pharmacotherapy. 2015 Feb;35(2):189-97. doi: 10.1002/phar.1522. Epub 2014 Dec 4. Review.
Comments: Desomorphine. Blech.
Haegerich TM, Paulozzi LJ, Manns BJ, Jones CM.
Drug Alcohol Depend. 2014 Dec 1;145:34-47. doi: 10.1016/j.drugalcdep.2014.10.001. Epub 2014 Oct 14. Review.
Comments: Not much.
Chakrapani V, Kamei R, Kipgen H, Kh JK.
Int J Prison Health. 2013;9(2):82-91. doi: 10.1108/17449201311326952.
Comments: Access is … no there.
Tacelosky DM, Alexander DN, Morse M, Hajnal A, Berg A, Levenson R, Grigson PS.
Behav Neurosci. 2015 Oct 26. [Epub ahead of print]
Comments: Holding drug exposure constant, reducing dopamine D2 receptors or that other thing (Wntless) results in more opioid craving.
Allread V, Paul S.
MD Advis. 2014 Fall;7(4):12-20. Review.
Comments: Can’t access. Review for New Jersey and rest of US regarding prescription opioids and heroin use.